Recently one of my agencies asked me about CBD – what is it and what are its effects and implications for EMS? I realized this is probably a good topic to review overall since it is changing so quickly. But first, lets start at the beginning – with marijuana, more appropriately known as Cannabis
It is believed that cannabis as a crop has been cultivated for thousands of years starting in Central Asia. Reportedly, it was known as one of the five grains of China starting in 4000 BC. From a western perspective, the Dutch found that South Africa was using it in 1652.
Cannabis is a genus of flowering plant in the Cannabaceae family. There are three types, Cannabis Sativa, Cannabis indica and Cannabis ruderalis. The primary psychoactive substance in cannabis is THC: Delta-9 tetrahydrocannabinol. This is isolated in 1964 and identified as the primary psychoactive substance relatively recently in 2002. There are many other psychoactive substances or cannabinoids – perhaps as many as 100 in the cannabis plant. In a regular cannabis plant, the THC is located in the leaves, flowers, seeds and stems with about 10-20% concentration of THC.
THC binds to the CB1 and CB2 receptors in the endocannabinoid system of the body, and this results in the high. These receptors are located throughout the body, and their activation (or connection of the chemical and the receptor) inhibits cellular excitation – it is sedating. One area they are not located is in the brainstem, so there is normally no life threatening autonomic dysfunction (heart rate, blood pressure) from actual THC use.
What THC exposure does result in is the perceived ‘high’ – it affects perception and cognitive and psychomotor performance. The typical method of use was and is by smoking parts of the cannabis plant. The bioavailability (or the amount of THC actually getting in the body) is about 35%. The peak effects are in about 8 minutes, and after smoking, the user can have normal function in 2-3 hours.
An alternative method of use is by ingestion – the prototypical brownie baked with THC. In this case normal function results in 4-8 hours after ingestion. However, after recreational use was legalized in certain states, marijuana edibles became more common. The problem is that these have a significantly higher concentration of THC than many users were used to. They also take longer to take effect so users that were accustomed to smoking and feeling it right away, would pop two or three before the first one would take affect. Some forms have looked like candy, and the risk to children is significant.
Hashish is a solid or resinous preparation of the glandular hairs that grow on flowers. The powder is called ‘kief’ and it is compressed into blocks or bricks. The THC can be as high as 66%
Hash Oil or Butane Hash Oil is further purified, the resin is dissolved and the plant material is filtered out. THC can be as high as 80%. Butane can be used for the extraction, and there is risk of fires during its production. It is available commercially where MJ is legal. Often a metal object or nail is heated by a blow torch to very high temperatures and then it is inhaled – dabbing. It can also be used in e-cigs and vaping products.
Cannabinoid Hyperemesis Syndrome
CHS was first described in 2004. Its cause is unknown, but results in severe vomiting, nausea and abdominal pain in those that have used cannabis almost daily for a year or more. As recreational cannabis has become legal in more and more states, we are seeing more cases of this.
One possible cause is the desensitization of the CB1 receptor and dysregulation of cannabinoid system. This results in gastric slowing and hyperemesis. Chronic cannabis use may also inactivate the TRPV1 receptor, which is involved in gastric motility.
Treatment is symptomatic. There is no test to be run so it is helpful to get a good and accurate history. Normal treatments such as Zofran, Reglan and opioids for pain are less effective. An interesting treatment is a hot shower or bath, which causes rapid relief. The heat may reactivate the TRPV1 receptor. Topical capsaicin is also effective, and can be applied 3-4 times per day. For nausea and vomiting, Haldol is effective within 1-2 hours. The condition will resolve in 7-10 days after decreased use.
From a legal perspective, the US Government started restricting cannabis in the 1930s, and in 1970 it was made a Schedule I drug by the DEA. This means it is illegal and has no medical use, not even research, by their definition.
The use of cannibis is legal for medicinal purposes in at least 33 states and DC. The vast majority of Americans approve of it for this purpose. Doctors don’t prescribe it but rather ‘approve’ or ‘certify’ a patient for it if they have certain conditions, which are different in every state. Some of its indications may include chronic pain, nausea and spasms.
Hemp is a variety of cannabis that has less than 0.3% THC. This is a legal definition per the Agricultural Act of 2018 that made hemp legal. Hemp has a variety of uses including rope, cloth, paper, housing material.
SC has been around since the 1940s when individuals were trying to modify some components of THC. The current re-emergency started in 1993 when a scientist John W. Hoffman synthesized JWH-018. He was attempting to isolate the medical qualities such as anti-nausea medication, but the resultant products caused a more intense high, psychosis, seizures and heart attacks. One report is that since he was using federal grant money he had to publish his data, and new recreational chemists seized on this recipe.
SC is actually not similar to THC. It can be sprayed on plant material and smoked, or formed as a liquid for vaping. It is low cost, and does not show up on a drug screen.
CBD is known as cannabidiol, the second most common of the ingredients of the cannabis. It is an extract from flowers and buds of hemp or cannabis, and if from the hemp plant it is legal in most states. If pure, CBD has no psychoactive properties so no high.
The problem with CBD is it is a supplement as defined by the FDA, so it is unregulated. Buyers have no idea what they are really getting. There have been multiple cases where the CBD oil was actually a synthetic cannabinoid and caused severe symptoms such as altered mental status, seizures, shaking, nausea and vomiting.
The evidence that it helps medical conditions is scant, but it seems that it may benefit two childhood seizure conditions – Dravert Syndrome and Lennox-Gastart Syndrome. The FDA recently approved an oral form of cannabidiol for these conditions, called Epidiolex.
The effective dose is unknown. The side effects include nausea, fatigue and irritability. It can affect warfarin levels similar to grapefruit and other foods.
In general, regular marijuana smoking is unlikely to cause a significant issue for EMS. Cannabidiol, if pure, is also unlikely to cause any issues because there is no high associated with it. Synthetic Cannadinoids can and will cause psychosis and other severe forms of altered mental status. However it is important to understand that these substances can be mixed – we never really know what we are going to get.
It makes me intend to release her, guide her to the bed in the placement that is my favourite, and also it makes me
desire to take her, to wail with her. It makes me wish to pump her till my penis pulsates
as well as dumps my cozy bumped into her face.
Several laugh at the idea when a person states I am
going to Leash train my Slave or Submissive. The chain can have an excellent influence on the Slave/ Submissive.
Other article abouta Leash And Collar BdsmThe Master would teach commands not with words however with activities of the leash.
Pulling down on the chain indicates you wish for your own to stoop, drawing up shows you want for them to stand.
Educating the slave the different motions without speaking is not as simple as it sounds.
You are teaching the Slave/Submissive to adhere to on your commands without speaking.
Remaining on a path you establish aids set criteria.
Much more so the Submissive/Slave knows what is anticipated.
To take it one action farther You can make use of cuffs, behind their back.
This offer the Master overall control, and also the Slave/Submissive will certainly need to focus on your
commands. The commands are much like the commands you would offer if you use slave placements in your
Recently Arianna and also I was speaking and I was going to
transform the method she greeted me. She did greet me on knees bent onward
with arms extended out face down. I instructed her I now desired servant placement # 2 The exact same however
facing away from me hands on ass spreading apart.
leash for bdsm.
Recently Arianna and I was chatting as well as I was mosting likely to alter the method she welcomed me.
She did greet me on knees curved onward with arms
extended face down. I advised her I now desired slave setting # 2 The same however encountering away from me hands on butt dispersing
In the first setting she really felt more like a slave and also explained while in that setting she had a huge smile
on her face since I was residence, as well as she might not wait to see me.
So after we spoke I made that adjustment. It absolutely makes Arianna honored to kneel and also await
me to stroll via the door.
While chain training when you are speaking all eyes should be on you.
You can tell when someone is paying attention and when they are not and you
make the corrections with a small pull on the Chain.
I did not truly expect any comments, but during bike week I
have seen method crazier crap than some bitch using a collar and also leash.
I have not providing much thought to training Arianna with a
I have offering it some assumed in the past, and I may extremely
well here in the future. The Collar when placed about their neck provides
a sensation of being complete. They have actually functioned so tough to gain.
They have offering extra in six months to a year than they have
ever giving. versace bondage belt bag.
There is way greater than simply the feeling of being owned.
After that you include the Chain. You the Dominant are
now completely control. If the Servant or Submissive is in the best mindset it will certainly take them locations they have actually never
ever been in the past. Overall power exchange. They currently recognize they must follow without doubt.
Read this article about Chastity Belt Plug BondageUtilized on an everyday basis they will soon adjust,
and will most likely welcome the Chain when you bring it out.
One thing you never ever use is a choker collar, never ever, never ever, never.
I needed to draft you that little remark to finally thank you so much as before for your amazing guidelines you have featured at this time. It’s quite wonderfully generous of you to grant unhampered what exactly many people could have supplied as an electronic book to generate some profit for their own end, primarily considering the fact that you might well have tried it if you ever considered necessary. The ideas also worked like a good way to comprehend other people online have similar interest much like mine to understand good deal more concerning this condition. I am certain there are many more pleasurable periods in the future for individuals that read through your website.
Very interesting information!Perfect just what I was searching for!
I like what you guys are up too. Such intelligent work and reporting! Carry on the excellent works guys I have incorporated you guys to my blogroll. I think it’ll improve the value of my site :).
Today, while I was at work, my cousin stole my iphone and tested to see if it can survive a twenty five foot drop, just so she can be a youtube sensation. My apple ipad is now broken and she has 83 views. I know this is totally off topic but I had to share it with someone!
Almost all of what you assert is supprisingly precise and that makes me ponder the reason why I hadn’t looked at this in this light before. Your article truly did switch the light on for me as far as this specific topic goes. Nevertheless there is actually one issue I am not necessarily too comfortable with and while I try to reconcile that with the central idea of your position, let me observe what all the rest of the subscribers have to point out.Well done.
Artificial intelligence creates content for the site, no worse than a copywriter, you can also use it to write articles. 100% uniqueness, scheduled posting to your WordPress :). Click Here:👉 https://stanford.io/3FXszd0
1xbet promo code 2023. Click Here:👉 https://www.aamas.org/news/1xbet_free_code_registration.html
промокод мелбет без депозита. Click Here:👉 https://mebel-3d.ru/libraries/news/?melbet_2020_promokod_dlya_registracii_besplatno.html
Sign Up to receive a Bonus.Free bonus up to 0.9ETH .Instant payments on MetaMask https://bit.ly/3noCPDL